LMPD Database

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LMP002048

UniProt Annotations

Entry Information
Gene Namebeta-carotene oxygenase 1
Protein EntryBCDO1_HUMAN
UniProt IDQ9HAY6
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityBeta-carotene + O(2) = 2 all-trans-retinal.
CofactorName=Fe(2+); Xref=ChEBI
DiseaseHypercarotenemia and vitamin A deficiency, autosomal dominant (ADHVAD) [MIM
FunctionSymmetrically cleaves beta-carotene into two molecules of retinal. The reaction proceeds in three stages, epoxidation of the 15,15'-double bond, hydration of the double bond leading to ring opening, and oxidative cleavage of the diol formed.
PathwayCofactor metabolism; retinol metabolism.
SimilarityBelongs to the carotenoid oxygenase family.
Tissue SpecificityHighly expressed in retinal pigment epithelium. Also expressed in kidney, testis, liver, brain, small intestine and colon.