LMPD Database

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LMP002048

Record overview

LMPD IDLMP002048
Gene ID53630
SpeciesHomo sapiens (Human)
Gene Namebeta-carotene oxygenase 1
Gene SymbolBCO1
SynonymsBCDO; BCDO1; BCMO; BCMO1; BCO
Alternate namesbeta,beta-carotene 15,15'-monooxygenase;,beta-carotene dioxygenase 1', "beta-carotene 15, 15'-dioxygenase 1", "beta-carotene 15,15'-monooxygenase 1
Chromosome16
Map Location16q23.2
EC Number1.14.99.36
SummaryVitamin A metabolism is important for vital processes such as vision, embryonic development, cell differentiation, and membrane and skin protection. The protein encoded by this gene is a key enzyme in beta-carotene metabolism to vitamin A. It catalyzes the oxidative cleavage of beta,beta-carotene into two retinal molecules. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for BCO1

Proteins

beta,beta-carotene 15,15'-monooxygenase
Refseq ID:NP_059125
Protein GI:74027270
UniProt ID:Q9HAY6
mRNA ID:NM_017429
Length:547
RefSeq Status:REVIEWED
MDIIFGRNRKEQLEPVRAKVTGKIPAWLQGTLLRNGPGMHTVGESRYNHWFDGLALLHSFTIRDGEVYYRSKYLRSDTYNTNIEANRIVVSEFGTMAYPD
PCKNIFSKAFSYLSHTIPDFTDNCLINIMKCGEDFYATSETNYIRKINPQTLETLEKVDYRKYVAVNLATSHPHYDEAGNVLNMGTSIVEKGKTKYVIFK
IPATVPEGKKQGKSPWKHTEVFCSIPSRSLLSPSYYHSFGVTENYVIFLEQPFRLDILKMATAYIRRMSWASCLAFHREEKTYIHIIDQRTRQPVQTKFY
TDAMVVFHHVNAYEEDGCIVFDVIAYEDNSLYQLFYLANLNQDFKENSRLTSVPTLRRFAVPLHVDKNAEVGTNLIKVASTTATALKEEDGQVYCQPEFL
YEGLELPRVNYAHNGKQYRYVFATGVQWSPIPTKIIKYDILTKSSLKWREDDCWPAEPLFVPAPGAKDEDDGVILSAIVSTDPQKLPFLLILDAKSFTEL
ARASVDVDMHMDLHGLFITDMDWDTKKQAASEEQRDRASDCHGAPLT