LMPD Database

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LMP001913

UniProt Annotations

Entry Information
Gene Namepleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Protein EntryPKHA1_HUMAN
UniProt IDQ9HB21
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9HB21-1; Sequence=Displayed; Name=2; IsoId=Q9HB21-2; Sequence=VSP_043091; Note=No experimental confirmation available.;
DomainBinds to membranes enriched in PtdIns3,4P2 via the C- terminal PH domain.
FunctionBinds specifically to phosphatidylinositol 3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO
InteractionO75970:MPDZ; NbExp=6; IntAct=EBI-2652984, EBI-821405; Q9P0V3:SH3BP4; NbExp=2; IntAct=EBI-2652984, EBI-1049513;
SimilarityContains 2 PH domains. {ECO
Subcellular LocationCytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2.
SubunitInteracts with MPDZ and PTPN13.
Tissue SpecificityHighly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.