LMPD Database

LMP001913

Record overview

LMPD ID	LMP001913
Gene ID	59338
Species	Homo sapiens (Human)
Gene Name	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
Gene Symbol	PLEKHA1
Synonyms	TAPP1
Chromosome	10
Map Location	10q26.13
Summary	This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.[provided by RefSeq, Sep 2010]
Orthologs	View orthologs and multiple alignments for PLEKHA1

Proteins

pleckstrin homology domain-containing family A member 1 isoform 1

Refseq ID:	NP_067635
Protein GI:	31377720
UniProt ID:	Q9HB21
mRNA ID:	NM_021622
Length:	404
RefSeq Status:	REVIEWED

MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDL
VEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQDSAVIKAGYCVK
QGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS
EHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLP
VSDV

pleckstrin homology domain-containing family A member 1 isoform 1

Refseq ID:	NP_001001974
Protein GI:	50234893
UniProt ID:	Q9HB21
mRNA ID:	NM_001001974
Length:	404
RefSeq Status:	REVIEWED

pleckstrin homology domain-containing family A member 1 isoform 2
Protein sequence is identical to GI:31377720 (mRNA isoform)

Refseq ID:	NP_001182537
Protein GI:	307344641
UniProt ID:	Q9HB21
mRNA ID:	NM_001195608
Length:	334
RefSeq Status:	REVIEWED

`MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDL VEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQDSAVIKAGYCVK QGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASS MRQARRLSNPCIQRYTSRAGECSTYVGSHANVPS`