LMPD Database

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LMP001867

UniProt Annotations

Entry Information
Gene Nameretinoic acid receptor, beta
Protein EntryF1D8S6_HUMAN
UniProt IDQ86UC5
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=Beta-1; IsoId=P10826-1; Sequence=Displayed; Name=Beta-2; IsoId=P10826-2; Sequence=VSP_003634; Name=Beta-3; IsoId=P10826-4; Sequence=Not described; Name=Beta-4; IsoId=P10826-3; Sequence=VSP_003635;
DiseaseMicrophthalmia, syndromic, 12 (MCOPS12) [MIM
DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
FunctionReceptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
InteractionP03255:- (xeno); NbExp=2; IntAct=EBI-8583223, EBI-2603114;
Sequence CautionSequence=CAA27637.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationIsoform Beta-1: Nucleus.
Subcellular LocationIsoform Beta-2: Nucleus.
Subcellular LocationIsoform Beta-4: Cytoplasm.
SubunitHomodimer (By similarity). Heterodimer; with a RXR molecule. Binds DNA preferentially as a RAR/RXR heterodimer (By similarity). Interacts weakly with NCOR2. {ECO