LMPD Database

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LMP001867

Record overview

LMPD IDLMP001867
Gene ID5915
SpeciesHomo sapiens (Human)
Gene Nameretinoic acid receptor, beta
Gene SymbolRARB
SynonymsHAP; MCOPS12; NR1B2; RRB2
Chromosome3
Map Location3p24.2
SummaryThis gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]
OrthologsView orthologs and multiple alignments for RARB

Proteins

retinoic acid receptor beta isoform 1
Refseq ID:NP_000956
Protein GI:14916494
UniProt ID:Q86UC5
mRNA ID:NM_000965
Length:448
RefSeq Status:REVIEWED
MFDCMDVLSVSPGQILDFYTASPSSCMLQEKALKACFSGLTQTEWQHRHTAQSIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHYGVSACEG
CKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGK
YTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD
LVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMP
PLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
 
retinoic acid receptor beta isoform 2
Refseq ID:NP_001277146
Protein GI:590122018
UniProt ID:Q5QHG3
mRNA ID:NM_001290217
Length:336
RefSeq Status:REVIEWED
MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVR
LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPL
EMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
HEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
 
retinoic acid receptor beta isoform 2
Refseq ID:NP_057236
Protein GI:7706625
UniProt ID:Q5QHG3
mRNA ID:NM_016152
Length:336
RefSeq Status:REVIEWED
Protein sequence is identical to GI:590122018 (mRNA isoform)
 
retinoic acid receptor beta isoform 2
Refseq ID:NP_001277205
Protein GI:590122040
UniProt ID:Q86UC5
mRNA ID:NM_001290276
Length:336
RefSeq Status:REVIEWED
Protein sequence is identical to GI:590122018 (mRNA isoform)
 
retinoic acid receptor beta isoform 3
Refseq ID:NP_001277145
Protein GI:590122016
UniProt ID:P10826
mRNA ID:NM_001290216
Length:455
RefSeq Status:REVIEWED
MTTSGHACPVPAVNGHMTHYPATPYPLLFPPVIGGLSLPPLHGLHGHPPPSGCSTPSPATIETQSTSSEELVPSPPSPLPPPRVYKPCFVCQDKSSGYHY
GVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFP
SLCQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNA
GFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKM
EIPGSMPPLIQEMLENSEGHEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
 
retinoic acid receptor beta isoform 4
Refseq ID:NP_001277195
Protein GI:590122018
UniProt ID:P10826
mRNA ID:NM_001290266
Length:336
RefSeq Status:REVIEWED
MIYTCHRDKNCVINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKETSKQECTESYEMTAELDDLTEKIRKAHQETFPSLCQLGKYTTNSSADHRVR
LDLGLWDKFSELATKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFTFANQLLPL
EMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEG
HEPLTPSSSGNTAEHSPSISPSSVENSGVSQSPLVQ
 
retinoic acid receptor beta isoform 6
Refseq ID:NP_001277229
Protein GI:590122040
UniProt ID:Q3SB16
mRNA ID:NM_001290300
Length:336
RefSeq Status:REVIEWED
Protein sequence is identical to GI:590122018 (mRNA isoform)