LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001844

UniProt Annotations

Entry Information
Gene Namearachidonate 5-lipoxygenase-activating protein
Protein EntryAL5AP_HUMAN
UniProt IDP20292
SpeciesHuman
Comments
Comment typeDescription
DiseaseIschemic stroke (ISCHSTR) [MIM
DiseaseNote=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
DomainThe C-terminal part after residue 140 is mostly unstructured.
FunctionRequired for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. {ECO
SimilarityBelongs to the MAPEG family.
Subcellular LocationNucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
SubunitHomotrimer. Interacts with LTC4S and ALOX5.
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/alox5ap/";