LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001838

UniProt Annotations

Entry Information
Gene Namelipase, member H
Protein EntryLIPH_HUMAN
UniProt IDQ8WWY8
SpeciesHuman
Comments
Comment typeDescription
DiseaseHypotrichosis 7 (HYPT7) [MIM
DiseaseWoolly hair autosomal recessive 2 (ARWH2) [MIM
Enzyme RegulationInhibited by sodium vanadate.
FunctionHydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG).
Sequence CautionSequence=BAB85023.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
SimilarityBelongs to the AB hydrolase superfamily. Lipase family.
Subcellular LocationSecreted. Membrane; Peripheral membrane protein.
Tissue SpecificityPresent in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region. {ECO