LMPD Database

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LMP001754

UniProt Annotations

Entry Information
Gene NameST3 beta-galactoside alpha-2,3-sialyltransferase 6
Protein EntrySIA10_HUMAN
UniProt IDQ9Y274
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y274-1; Sequence=Displayed; Name=2; IsoId=Q9Y274-2; Sequence=VSP_047009, VSP_047010;
FunctionInvolved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3- sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.
SimilarityBelongs to the glycosyltransferase 29 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Tissue SpecificityUbiquitous.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST3Gal VI; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_627";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL6";