LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001754

Record overview

LMPD IDLMP001754
Gene ID10402
SpeciesHomo sapiens (Human)
Gene NameST3 beta-galactoside alpha-2,3-sialyltransferase 6
Gene SymbolST3GAL6
SynonymsSIAT10; ST3GALVI
Alternate namestype 2 lactosamine alpha-2,3-sialyltransferase; alpha2,3-sialyltransferase ST3Gal VI; sialyltransferase 10 (alpha-2,3-sialyltransferase VI); CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
Chromosome3
Map Location3q12.1
EC Number2.4.99.-
SummaryThe protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Sep 2012]
OrthologsView orthologs and multiple alignments for ST3GAL6

Proteins

type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
Refseq ID:NP_001258075
Protein GI:403225034
UniProt ID:Q9Y274
mRNA ID:NM_001271146
Length:331
RefSeq Status:REVIEWED
MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLLRFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSK
LQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLEL
LMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSL
MNKNAYHNVTAEQLFLKDIIEKNLVINLTQD
 
type 2 lactosamine alpha-2,3-sialyltransferase isoform 1
Refseq ID:NP_006091
Protein GI:5174697
UniProt ID:Q9Y274
mRNA ID:NM_006100
Length:331
RefSeq Status:REVIEWED
Protein sequence is identical to GI:403225034 (mRNA isoform)
 
type 2 lactosamine alpha-2,3-sialyltransferase isoform 3
Refseq ID:NP_001258074
Protein GI:403225032
UniProt ID:Q9Y274
mRNA ID:NM_001271145
Length:384
RefSeq Status:REVIEWED
MWQAPRERQQPAGAAAPQVSEPGAPLRSSLLGLGGSLLPAGFAAGLHCPGEPAMRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLS
KPAFASLLRFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNN
GPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKV
FPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNLVINLTQD
 
type 2 lactosamine alpha-2,3-sialyltransferase isoform 4
Refseq ID:NP_001258076
Protein GI:403225036
UniProt ID:Q9Y274
mRNA ID:NM_001271147
Length:213
RefSeq Status:REVIEWED
MRTSAEYFRLALSKLQSCDLFDEFDKMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALN
LIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKD
IIEKNLVINLTQD