LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001600

UniProt Annotations

Entry Information
Gene Nameprotein geranylgeranyltransferase type I, beta subunit
Protein EntryPGTB1_HUMAN
UniProt IDP53609
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=P53609-1; Sequence=Displayed; Name=2; IsoId=P53609-2; Sequence=VSP_021827; Note=No experimental confirmation available.;
Catalytic ActivityGeranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
CofactorName=Zn(2+); Xref=ChEBI
FunctionCatalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include RAC1, RAC2, RAP1A and RAP1B.
SimilarityBelongs to the protein prenyltransferase subunit beta family.
SimilarityContains 4 PFTB repeats.
SubunitHeterodimer of FNTA and PGGT1B. PGGT1B mediates interaction with substrate peptides.