LMPD Database

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LMP001600

Record overview

LMPD IDLMP001600
Gene ID5229
SpeciesHomo sapiens (Human)
Gene Nameprotein geranylgeranyltransferase type I, beta subunit
Gene SymbolPGGT1B
SynonymsBGGI; GGTI
Alternate namesgeranylgeranyl transferase type-1 subunit beta; GGTase-I-beta; geranylgeranyltransferase type I beta subunit; geranylgeranyl transferase type I subunit beta; type I protein geranyl-geranyltransferase subunit beta
Chromosome5
Map Location5q22.3
EC Number2.5.1.59
SummaryProtein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase.[supplied by OMIM, Mar 2010]
OrthologsView orthologs and multiple alignments for PGGT1B

Proteins

geranylgeranyl transferase type-1 subunit beta
Refseq ID:NP_005014
Protein GI:167860116
UniProt ID:P53609
mRNA ID:NM_005023
Length:377
RefSeq Status:VALIDATED
MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSY
LGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYI
RRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST