LMPD Database

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LMP001592

UniProt Annotations

Entry Information
Gene Namemevalonate (diphospho) decarboxylase
Protein EntryMVD1_HUMAN
UniProt IDP53602
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate ; KM=0.32 mM for ATP ;
Catalytic ActivityATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).
FunctionPerforms the first committed step in the biosynthesis of isoprenes.
PathwaySteroid biosynthesis; cholesterol biosynthesis.
SimilarityBelongs to the diphosphomevalonate decarboxylase family.
SubunitHomodimer.
Tissue SpecificityExpressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.