LMPD Database

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LMP001592

Record overview

LMPD IDLMP001592
Gene ID4597
SpeciesHomo sapiens (Human)
Gene Namemevalonate (diphospho) decarboxylase
Gene SymbolMVD
SynonymsFP17780; MPD
Alternate namesdiphosphomevalonate decarboxylase; MDDase; mevalonate pyrophosphate decarboxylase; mevalonate pyrophosphate decarboxylase
Chromosome16
Map Location16q24.3
EC Number4.1.1.33
SummaryThe enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MVD

Proteins

diphosphomevalonate decarboxylase
Refseq ID:NP_002452
Protein GI:4505289
UniProt ID:P53602
mRNA ID:NM_002461
Length:400
RefSeq Status:REVIEWED
MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLSVTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRLQACLREIRCLARKRRNSRDGD
PLPSSLSCKVHVASVNNFPTAAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELRVLIL
VVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPARMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPISYLNAISWRIIHLVHRFNAHHGDTKV
AYTFDAGPNAVIFTLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSAELQAALAMEPTPGGVKYIIVTQVGPGPQILDDPCAHLLGPDGLPKPAA