LMPD Database

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LMP001565

UniProt Annotations

Entry Information
Gene Namesphingomyelin phosphodiesterase 2, neutral
Protein EntryNSMA_MOUSE
UniProt IDO70572
SpeciesMouse
Comments
Comment typeDescription
Biophysicochemical PropertiespH dependence: Optimum pH is 6.5-7.5.;
Catalytic ActivitySphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
CofactorName=Mg(2+); Xref=ChEBI:CHEBI:18420;
Disruption PhenotypeMice lacking Smpd2 and Smpd3 are completely devoid of neutral SMase activity but do not developed sphingomyelin storage abnormalities. {ECO:0000269|PubMed:15764706}.
FunctionConverts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF (By similarity). {ECO:0000250}.
PathwayLipid metabolism; sphingolipid metabolism.
SimilarityBelongs to the neutral sphingomyelinase family. {ECO:0000305}.
Subcellular LocationMembrane; Multi-pass membrane protein.
Tissue SpecificityAlthough widely expressed in all tissues examined, except the spleen, high enzymatic activity occurs only in the brain. {ECO:0000269|PubMed:9520418}.