LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP001475

UniProt Annotations

Entry Information
Gene Namesterol regulatory element binding transcription factor 2
Protein EntrySRBP2_HUMAN
UniProt IDQ12772
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q12772-1; Sequence=Displayed; Name=2; IsoId=Q12772-2; Sequence=VSP_054283, VSP_054284, VSP_054285; Note=No experimental confirmation available.;
FunctionTranscriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') found in the flanking region of the LDRL and HMG-CoA synthase genes.
InteractionP08047:SP1; NbExp=3; IntAct=EBI-465059, EBI-298336; P04637:TP53; NbExp=3; IntAct=EBI-465059, EBI-366083;
PtmAt low cholesterol the SCAP/SREBP complex is recruited into COPII vesicles for export from the ER. In the Golgi complex SREBPs are cleaved sequentially by site-1 and site-2 protease. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain and releases the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7. {ECO
PtmPhosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression.
Sequence CautionSequence=AAH51799.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the SREBP family.
SimilarityContains 1 bHLH (basic helix-loop-helix) domain.
Subcellular LocationEndoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
Subcellular LocationProcessed sterol regulatory element-binding protein 2: Nucleus.
SubunitForms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. Component of SCAP/SREBP complex composed of SREBF2, SCAP and RNF139; the complex hampers the interaction between SCAP and SEC24B, thereby reducing SREBF2 proteolytic processing. Interacts (via C-terminal domain) with RNF139.
Tissue SpecificityUbiquitously expressed in adult and fetal tissues.