LMPD Database

LMP001475

Gene Information

Entrez Gene ID	6721
Gene Name	sterol regulatory element binding transcription factor 2
Gene Symbol	SREBF2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:UniProtKB	C	cytoplasm
GO:0031410	IEA:UniProtKB-KW	C	cytoplasmic vesicle
GO:0005829	TAS:Reactome	C	cytosol
GO:0005783	IDA:UniProtKB	C	endoplasmic reticulum
GO:0005789	TAS:Reactome	C	endoplasmic reticulum membrane
GO:0000139	TAS:Reactome	C	Golgi membrane
GO:0005730	IDA:HPA	C	nucleolus
GO:0005654	TAS:Reactome	C	nucleoplasm
GO:0005634	IDA:UniProtKB	C	nucleus
GO:0032937	IDA:UniProtKB	C	SREBP-SCAP-Insig complex
GO:0070888	IDA:BHF-UCL	F	E-box binding
GO:0008022	IPI:UniProtKB	F	protein C-terminus binding
GO:0000978	IDA:BHF-UCL	F	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003700	IEA:Ensembl	F	sequence-specific DNA binding transcription factor activity
GO:0044255	TAS:Reactome	P	cellular lipid metabolic process
GO:0071499	NAS:BHF-UCL	P	cellular response to laminar fluid shear stress
GO:0008203	IEA:UniProtKB-KW	P	cholesterol metabolic process
GO:0006629	TAS:ProtInc	P	lipid metabolic process
GO:0090370	IDA:BHF-UCL	P	negative regulation of cholesterol efflux
GO:0000122	IDA:BHF-UCL	P	negative regulation of transcription from RNA polymerase II promoter
GO:0010886	IDA:BHF-UCL	P	positive regulation of cholesterol storage
GO:0045944	IDA:UniProtKB	P	positive regulation of transcription from RNA polymerase II promoter
GO:2000188	IEA:Ensembl	P	regulation of cholesterol homeostasis
GO:0072368	IDA:BHF-UCL	P	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0055098	IEP:BHF-UCL	P	response to low-density lipoprotein particle
GO:0044281	TAS:Reactome	P	small molecule metabolic process
GO:0006351	IEA:UniProtKB-KW	P	transcription, DNA-templated

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_147904	Activation of gene expression by SREBF (SREBP)