Skip to main content

LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins

LMP001147

UniProt Annotations

Entry Information

Gene Name	lipase, family member N
Protein Entry	LIPN_HUMAN
UniProt ID	Q5VXI9
Species	Human

Comments

Comment type	Description
Developmental Stage	Up-regulated during epidermal differentiation.
Disease	Ichthyosis, congenital, autosomal recessive 8 (ARCI8) [MIM
Function	Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
Similarity	Belongs to the AB hydrolase superfamily. Lipase family.
Subcellular Location	Secreted .
Tissue Specificity	Highly expressed in the epidermis in the granular keratinocytes. Also detected in other tissues, although at much lower levels, including lung and spleen.