LMPD Database

LMP001147

Record overview

LMPD ID	LMP001147
Gene ID	643418
Species	Homo sapiens (Human)
Gene Name	lipase, family member N
Gene Symbol	LIPN
Synonyms	ARCI8; LI4; LIPL4; bA186O14.3
Alternate names	lipase member N; lipase-like abhydrolase domain-containing protein 4
Chromosome	10
Map Location	10q23.31
EC Number	3.1.1.-
Summary	The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011]
Orthologs	View orthologs and multiple alignments for LIPN

Proteins

lipase member N precursor

Refseq ID:	NP_001095939
Protein GI:	156447044
UniProt ID:	Q5VXI9
mRNA ID:	NM_001102469
Length:	398
RefSeq Status:	REVIEWED

MMWLLLTTTCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYAN
GSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALG
PTISFKYPTGIFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYH
SDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKAYS

sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1999
peptide sequence: 
MMWLLLTTTCLICGTLNA

mat_peptide: 19..398
product: Lipase member N
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q5VXI9.2)
calculated_mol_wt: 43554
peptide sequence: 
GGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGN
SRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKYPTGIFTRFFLL
PNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKH
YNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKAYS