LMPD Database

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LMP001130

UniProt Annotations

Entry Information
Gene Nameacyl-Coenzyme A dehydrogenase, medium chain
Protein EntryACADM_MOUSE
UniProt IDP45952
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityA medium-chain acyl-CoA + electron-transfer flavoprotein = a medium-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
CofactorName=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
FunctionThis enzyme is specific for acyl chain lengths of 4 to 16.
MiscellaneousA number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
PtmAcetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity. These sites are deacetylated by SIRT3 (By similarity). {ECO:0000250}.
SimilarityBelongs to the acyl-CoA dehydrogenase family. {ECO:0000305}.
Subcellular LocationMitochondrion matrix {ECO:0000250}.
SubunitHomotetramer. {ECO:0000250}.