LMPD Database

LMP001130

Record overview

LMPD IDLMP001130
Gene ID11364
SpeciesMus musculus(Mouse)
Gene Nameacyl-Coenzyme A dehydrogenase, medium chain
Gene SymbolAcadm
SynonymsAU018656; MCAD
Alternate namesmedium-chain specific acyl-CoA dehydrogenase, mitochondrial
Chromosome3
Map Location3 H3|3 78.77 cM
EC Number1.3.8.7
SummaryThis gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C6- and C12-acylCoA. In mice, deficiency of this gene can cause neonatal mortality as well as fasting and cold intolerance. This gene has multiple, intronless pseudogenes. [provided by RefSeq, Nov 2012]
OrthologsView orthologs and multiple alignments for Acadm

Proteins

medium-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID:NP_031408
Protein GI:6680618
UniProt ID:P45952
mRNA ID:NM_007382
Length:421
RefSeq Status:REVIEWED
MAAAFRRGCRVLRSVSHFECRTQHSKAAHKQEPGLGFSFELTEQQKEFQATARKFAREEIIPVAPEYDKSGEYPFPLIKRAWELGLINAHIPESCGGLGL
GTFDACLITEELAYGCTGVQTAIEANSLGQMPVILAGNDQQKKKYLGRMTEQPMMCAYCVTEPSAGSDVAAIKTKAEKKGDEYVINGQKMWITNGGKANW
YFLLARSNPDPKVPASKAFTGFIVEADTPGIHIGKKELNMGQRCSDTRGIAFEDVRVPKENVLIGEGAGFKIAMGAFDRTRPTVAAGAVGLAQRALDEAT
KYALDRKTFGKLLVEHQGVSFLLAEMAMKVELARLSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQIFGGYGFNTEYPVEKLMRDAKIYQIY
EGTAQIQRLIIAREHIEKYKN
 
transit_peptide: 1..25
inference: non-experimental evidence, no additional details recorded
note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P45952.1)
calculated_mol_wt: 2906
peptide sequence: 
MAAAFRRGCRVLRSVSHFECRTQHS

mat_peptide: 26..421
product: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P45952.1)
calculated_mol_wt: 43593
peptide sequence: 
KAAHKQEPGLGFSFELTEQQKEFQATARKFAREEIIPVAPEYDKSGEYPFPLIKRAWELGLINAHIPESCGGLGLGTFDACLITEELAYGCTGVQTAIEA
NSLGQMPVILAGNDQQKKKYLGRMTEQPMMCAYCVTEPSAGSDVAAIKTKAEKKGDEYVINGQKMWITNGGKANWYFLLARSNPDPKVPASKAFTGFIVE
ADTPGIHIGKKELNMGQRCSDTRGIAFEDVRVPKENVLIGEGAGFKIAMGAFDRTRPTVAAGAVGLAQRALDEATKYALDRKTFGKLLVEHQGVSFLLAE
MAMKVELARLSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQIFGGYGFNTEYPVEKLMRDAKIYQIYEGTAQIQRLIIAREHIEKYKN