LMPD Database

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LMP001120

Gene Information

Entrez Gene ID112398
Gene Nameegl-9 family hypoxia-inducible factor 2
Gene SymbolEGLN2
SpeciesHomo sapiens
Gene Ontology (GO Annotations)
GO IDSourceTypeDescription
GO:0005829 IEA:EnsemblCcytosol
GO:0005654 TAS:ReactomeCnucleoplasm
GO:0005634 IDA:UniProtKBCnucleus
GO:0008198 NAS:UniProtKBFferrous iron binding
GO:0031418 IEA:UniProtKB-KWFL-ascorbic acid binding
GO:0016706 IDA:UniProtKBFoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0019826 IDA:UniProtKBFoxygen sensor activity
GO:0031545 IDA:FlyBaseFpeptidyl-proline 4-dioxygenase activity
GO:0045454 IDA:UniProtKBPcell redox homeostasis
GO:0071456 TAS:ReactomePcellular response to hypoxia
GO:0030520 NAS:UniProtKBPintracellular estrogen receptor signaling pathway
GO:0018401 IDA:FlyBasePpeptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0045732 IDA:UniProtKBPpositive regulation of protein catabolic process
GO:0001558 NAS:UniProtKBPregulation of cell growth
GO:0043523 IMP:UniProtKBPregulation of neuron apoptotic process
GO:0061418 TAS:ReactomePregulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0001666 IDA:UniProtKBPresponse to hypoxia
KEGG Pathway Links
KEGG Pathway IDDescription
hsa04066HIF-1 signaling pathway
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
REACTOME Pathway Links
REACTOME Pathway IDDescription
REACT_120916Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha