LMPD Database

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LMP001120

Record overview

LMPD IDLMP001120
Gene ID112398
SpeciesHomo sapiens (Human)
Gene Nameegl-9 family hypoxia-inducible factor 2
Gene SymbolEGLN2
SynonymsEIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1
Alternate namesegl nine homolog 2; estrogen-induced tag 6; HIF-prolyl hydroxylase 1; hypoxia-inducible factor prolyl hydroxylase 1; prolyl hydroxylase domain-containing protein 1
Chromosome19
Map Location19q13.2
EC Number1.14.11.29
SummaryThe hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]
OrthologsView orthologs and multiple alignments for EGLN2

Proteins

egl nine homolog 2
Refseq ID:NP_542770
Protein GI:145701012
UniProt ID:Q96KS0
mRNA ID:NM_080732
Length:407
RefSeq Status:REVIEWED
MDSPCQPQPLSQALPQLPGSSSEPLEPEPGRARMGVESYLPCPLLPSYHCPGVPSEASAGSGTPRATATSTTASPLRDGFGGQDGGELRPLQSEGAAALV
TKGCQRLAAQGARPEAPKRKWAEDGGDAPSPSKRPWARQENQEAEREGGMSCSCSSGSGEASAGLMEEALPSAPERLALDYIVPCMRYYGICVKDSFLGA
ALGGRVLAEVEALKRGGRLRDGQLVSQRAIPPRSIRGDQIAWVEGHEPGCRSIGALMAHVDAVIRHCAGRLGSYVINGRTKAMVACYPGNGLGYVRHVDN
PHGDGRCITCIYYLNQNWDVKVHGGLLQIFPEGRPVVANIEPLFDRLLIFWSDRRNPHEVKPAYATRYAITVWYFDAKERAAAKDKYQLASGQKGVQVPV
SQPPTPT
 
egl nine homolog 2
Refseq ID:NP_444274
Protein GI:16604260
UniProt ID:Q96KS0
mRNA ID:NM_053046
Length:407
RefSeq Status:REVIEWED
Protein sequence is identical to GI:145701012 (mRNA isoform)