LMPD Database

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LMP001118

Record overview

LMPD IDLMP001118
Gene ID3931
SpeciesHomo sapiens (Human)
Gene Namelecithin-cholesterol acyltransferase
Gene SymbolLCAT
Synonyms-
Alternate namesphosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase
Chromosome16
Map Location16q22.1
EC Number2.3.1.43
SummaryThis gene encodes the extracellular cholesterol esterifying enzyme, lecithin-cholesterol acyltransferase. The esterification of cholesterol is required for cholesterol transport. Mutations in this gene have been found to cause fish-eye disease as well as LCAT deficiency. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LCAT

Proteins

phosphatidylcholine-sterol acyltransferase precursor
Refseq ID:NP_000220
Protein GI:4557892
UniProt ID:P04180
mRNA ID:NM_000229
Length:440
RefSeq Status:REVIEWED
MGPPGSPWQWVTLLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWI
DNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVF
LIGHSLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGR
DFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQ
HLNMVFSNLTLEHINAILLGAYRQGPPASPTASPEPPPPE
 
sig_peptide: 1..24
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2512
peptide sequence: 
MGPPGSPWQWVTLLLGLLLPPAAP

mat_peptide: 25..440
product: phosphatidylcholine-sterol acyltransferase
calculated_mol_wt: 47084
peptide sequence: 
FWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRKTEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRV
PGFGKTYSVEYLDSSKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGKPVFLIGHSLGCLHLLYFLLRQPQAWKD
RFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRITTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDL
LAGLPAPGVEVYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGIQHLNMVFSNLTLEHINAILLGAYRQ
GPPASPTASPEPPPPE