LMPD Database

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LMP001092

UniProt Annotations

Entry Information
Gene Nameplatelet-activating factor acetylhydrolase 2, 40kDa
Protein EntryPAFA2_HUMAN
UniProt IDQ99487
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
Enzyme RegulationInhibited by phenylmethanesulfonyl fluoride, 3,4,dichloroisocoumarin, diisopropyl fluorophosphate (DFP) and diethyl p-nitrophenyl phosphate (DENP).
FunctionHas a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme.
Mass SpectrometryMass=44162; Method=Electrospray; Range=1-392; Evidence= ;
SimilarityBelongs to the serine esterase family.
Subcellular LocationCytoplasm.
SubunitMonomer.
Tissue SpecificityBroadly expressed in different tissues, but high in B- and T-lymphocytes. In brain, expression is restricted to amygdala and frontal cortex.