LMPD Database

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LMP001092

Record overview

LMPD IDLMP001092
Gene ID5051
SpeciesHomo sapiens (Human)
Gene Nameplatelet-activating factor acetylhydrolase 2, 40kDa
Gene SymbolPAFAH2
SynonymsHSD-PLA2
Alternate namesplatelet-activating factor acetylhydrolase 2, cytoplasmic; SD-PLA2; serine-dependent phospholipase A2
Chromosome1
Map Location1p36
EC Number3.1.1.47
SummaryThis gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PAFAH2

Proteins

platelet-activating factor acetylhydrolase 2, cytoplasmic
Refseq ID:NP_000428
Protein GI:4758878
UniProt ID:Q99487
mRNA ID:NM_000437
Length:392
RefSeq Status:REVIEWED
MGVNQSVGFPPVTGPHLVGCGDVMEGQNLQGSFFRLFYPCQKAEETMEQPLWIPRYEYCTGLAEYLQFNKRCGGLLFNLAVGSCRLPVSWNGPFKTKDSG
YPLIIFSHGLGAFRTLYSAFCMELASRGFVVAVPEHRDRSAATTYFCKQAPEENQPTNESLQEEWIPFRRVEEGEKEFHVRNPQVHQRVSECLRVLKILQ
EVTAGQTVFNILPGGLDLMTLKGNIDMSRVAVMGHSFGGATAILALAKETQFRCAVALDAWMFPLERDFYPKARGPVFFINTEKFQTMESVNLMKKICAQ
HEQSRIITVLGSVHRSQTDFAFVTGNLIGKFFSTETRGSLDPYEGQEVMVRAMLAFLQKHLDLKEDYNQWNNLIEGIGPSLTPGAPHHLSSL