LMPD Database

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LMP001087

UniProt Annotations

Entry Information
Gene Namelanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Protein EntryERG7_HUMAN
UniProt IDP48449
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P48449-1; Sequence=Displayed; Name=2; IsoId=P48449-2; Sequence=VSP_045407; Note=No experimental confirmation available.; Name=3; IsoId=P48449-3; Sequence=VSP_046188; Note=No experimental confirmation available.;
Catalytic Activity(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol. {ECO
FunctionCatalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.
PathwayTerpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.
SimilarityBelongs to the terpene cyclase/mutase family.
SimilarityContains 4 PFTB repeats.
Subcellular LocationEndoplasmic reticulum membrane ; Peripheral membrane protein {ECO
SubunitMonomer.