LMPD Database

LMP001087

Record overview

LMPD IDLMP001087
Gene ID4047
SpeciesHomo sapiens (Human)
Gene Namelanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Gene SymbolLSS
SynonymsOSC
Chromosome21
Map Location21q22.3
EC Number5.4.99.7
SummaryThe protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
OrthologsView orthologs and multiple alignments for LSS

Proteins

lanosterol synthase isoform 1
Refseq ID:NP_002331
Protein GI:47933395
UniProt ID:P48449
mRNA ID:NM_002340
Length:732
RefSeq Status:REVIEWED
MTEGTCLRRRGGPYKTEPATDLGRWRLNCERGRQTWTYLQDERAGREQTGLEAYALGLDTKNYFKDLPKAHTAFEGALNGMTFYVGLQAEDGHWTGDYGG
PLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVL
NVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNVAPDELYTPHSWLLRVVYALL
NLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQGTNGSQIWDTAFAIQALLEAG
GHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPRERLCDAVAVLLNMRNPDGGF
ATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGSWGVCFTYGTWFGLEAFACMG
QTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEKQLPNGDWPQENIAGVFNKSC
AISYTSYRNIFPIWALGRFSQLYPERALAGHP
 
lanosterol synthase isoform 1
Refseq ID:NP_001001438
Protein GI:47933397
UniProt ID:P48449
mRNA ID:NM_001001438
Length:732
RefSeq Status:REVIEWED
Protein sequence is identical to GI:47933395 (mRNA isoform)
 
lanosterol synthase isoform 2
Refseq ID:NP_001138908
Protein GI:47933397
UniProt ID:P48449
mRNA ID:NM_001145436
Length:732
RefSeq Status:REVIEWED
Protein sequence is identical to GI:47933395 (mRNA isoform)
 
lanosterol synthase isoform 3
Refseq ID:NP_001138909
Protein GI:224177558
UniProt ID:P48449
mRNA ID:NM_001145437
Length:652
RefSeq Status:REVIEWED
MTFYVGLQAEDGHWTGDYGGPLFLLPGLLITCHVARIPLPAGYREEIVRYLRSVQLPDGGWGLHIEDKSTVFGTALNYVSLRILGVGPDDPDLVRARNIL
HKKGGAVAIPSWGKFWLAVLNVYSWEGLNTLFPEMWLFPDWAPAHPSTLWCHCRQVYLPMSYCYAVRLSAAEDPLVQSLRQELYVEDFASIDWLAQRNNV
APDELYTPHSWLLRVVYALLNLYEHHHSAHLRQRAVQKLYEHIVADDRFTKSISIGPISKTINMLVRWYVDGPASTAFQEHVSRIPDYLWMGLDGMKMQG
TNGSQIWDTAFAIQALLEAGGHHRPEFSSCLQKAHEFLRLSQVPDNPPDYQKYYRQMRKGGFSFSTLDCGWIVSDCTAEALKAVLLLQEKCPHVTEHIPR
ERLCDAVAVLLNMRNPDGGFATYETKRGGHLLELLNPSEVFGDIMIDYTYVECTSAVMQALKYFHKRFPEHRAAEIRETLTQGLEFCRRQQRADGSWEGS
WGVCFTYGTWFGLEAFACMGQTYRDGTACAEVSRACDFLLSRQMADGGWGEDFESCEERRYLQSAQSQIHNTCWAMMGLMAVRHPDIEAQERGVRCLLEK
QLPNGDWPQENIAGVFNKSCAISYTSYRNIFPIWALGRFSQLYPERALAGHP