LMPD Database

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LMP000912

UniProt Annotations

Entry Information
Gene Namefatty acid binding protein 2, intestinal
Protein EntryFABPI_HUMAN
UniProt IDP12104
SpeciesHuman
Comments
Comment typeDescription
DomainForms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
FunctionFABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
InductionBy EGF.
SimilarityBelongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
Subcellular LocationCytoplasm.
Tissue SpecificityExpressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum.