LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000871

UniProt Annotations

Entry Information
Gene Namephospholipase D2
Protein EntryPLD2_MOUSE
UniProt IDP97813
SpeciesMouse
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=1; Comment=At least 3 isoforms are produced.; Name=1; IsoId=P97813-1; Sequence=Displayed;
Catalytic ActivityA phosphatidylcholine + H(2)O = choline + a phosphatidate.
Developmental StageExpressed at high levels in the hippocampus at the earliest time at which it is defined as a structure and also in ventricular neural cells as well as differentiating neurons outside of the ventricular region. Expressed during development in lower levels in mesenchymal cells derived from the neural crest that are destined to form bones of the skull.
Enzyme RegulationStimulated by phosphatidylinositol 4,5- bisphosphate. Is not responsive to either ADP-ribosylation factor- 1 (ARF-1) or GTP-binding proteins such as RHOA.
FunctionMay have a role in signal-induced cytoskeletal regulation and/or endocytosis.
PtmPhosphorylated by FGR (By similarity). Phosphorylated on Tyr- 11; most likely by EGFR. {ECO:0000250, ECO:0000269|PubMed:9837959}.
SimilarityBelongs to the phospholipase D family. {ECO:0000305}.
SimilarityContains 1 PH domain. {ECO:0000305}.
SimilarityContains 1 PX (phox homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00147}.
SimilarityContains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular LocationMembrane; Peripheral membrane protein.
SubunitInteracts with PIP5K1B (By similarity). Interacts with EGFR. {ECO:0000250}.
Tissue SpecificityUbiquitous. Highest levels in brain and lung. {ECO:0000269|PubMed:9307024}.