LMPD Database

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LMP000871

Record overview

LMPD IDLMP000871
Gene ID18806
SpeciesMus musculus(Mouse)
Gene Namephospholipase D2
Gene SymbolPld2
SynonymsPLD1C
Alternate namesphospholipase D2; choline phosphatase 2; phosphatidylcholine-hydrolyzing phospholipase D2
Chromosome11
Map Location11 B3|11 42.99 cM
EC Number3.1.4.4
SummaryThis gene is a member of the phospholipase D (PLD) superfamily. The encoded protein catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. Phosphatidic acid is an essential intracellular lipid second messenger for many signaling pathways and has been implicated in a variety of physiological processes including cytoskeletal organization and cell proliferation. A similar gene in human may also function as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
OrthologsView orthologs and multiple alignments for Pld2

Proteins

phospholipase D2 isoform 2
Refseq ID:NP_032902
Protein GI:6679379
UniProt ID:P97813
mRNA ID:NM_008876
Length:933
RefSeq Status:REVIEWED
MTVTQKNLFPYGDYLNSSQLHMEPDEVDTLREGEDPADRMHPYLAIYDLQPLKAHPLVFAPGVPVIAQVVGTERYTSGSKVGTCTLYSVRLTHGDFTWTT
KKKFRHFQELHRDLQRHKVLMSLLPLARFAVTHSPAREAAAEDIPSLPRGGSEGSARHTASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDL
GSKGLEGVIRKRSGGHRVPGFTFCGRDQVCYRWSKRWLVVKDSFLLYMRPETGAISFVQLFDPGFEVQVGKRSTETRYGVRIDTSHRSLILKCSSYRQAR
WWGQEITELAQGSGRDFLQLHQHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEIYLKRPAHSDDWRLDIMLKRKAEEGVRVSIL
LFKEVELALGINSGYSKRTLMLLHPNIKVMRHPDLVTLWAHHEKLLVVDQVVAFLGGLDLAFGRWDDVQYRLTDLGDPSEPVHLQTPTLGSDPAATPDLS
HNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGVAARDLARHFIQRWNFTKTTKARYKTPLYPYLLPKSTSTANNLPFMIPGGQ
CATVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHEQGQCFRVYLLLPLLPGFEGDISTGGGNSIQ
AILHFTYRTLCRGEHSILHRLKAAMGTAWRDYMSICGLRTHGELGGHPISELIYIHSKMLIADDRTVIIGSANINDRSLLGKRDSELAILIKDTEMEPSL
MDGVEYQAGRFALSLRKHCFSVILGANTWPDLDLRDPVCDDFFQLWQETAENNATIYEQIFRCLPSNATRSLRALREYVAVESLATVSPSLAQSELAHIQ
GHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT