LMPD Database

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LMP000765

UniProt Annotations

Entry Information
Gene Name3-oxoacid CoA transferase 2
Protein EntrySCOT2_HUMAN
UniProt IDQ9BYC2
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivitySuccinyl-CoA + a 3-oxo acid = succinate + a 3- oxoacyl-CoA.
FunctionKey enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).
PathwayKetone metabolism; succinyl-CoA degradation; acetoacetyl- CoA from succinyl-CoA
SimilarityBelongs to the 3-oxoacid CoA-transferase family.
Subcellular LocationMitochondrion .
SubunitHomodimer.
Tissue SpecificityTestis specific.