LMPD Database

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LMP000599

UniProt Annotations

Entry Information
Gene Namecytochrome P450, family 7, subfamily B, polypeptide 1
Protein EntryCP7B1_HUMAN
UniProt IDO75881
SpeciesHuman
Comments
Comment typeDescription
Catalytic Activity(25R)-cholest-5-ene-3-beta,26-diol + NADPH + O(2) = (25R)-cholest-5-ene-3-beta,7-alpha,26-triol + NADP(+) + H(2)O.
Catalytic ActivityCholest-5-ene-3-beta,25-diol + NADPH + O(2) = cholest-5-ene-3-beta,7-alpha,25-triol + NADP(+) + H(2)O.
CofactorName=heme; Xref=ChEBI
DiseaseCongenital bile acid synthesis defect 3 (CBAS3) [MIM
DiseaseSpastic paraplegia 5A, autosomal recessive (SPG5A) [MIM
PathwayLipid metabolism; bile acid biosynthesis.
SimilarityBelongs to the cytochrome P450 family.
Subcellular LocationEndoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue SpecificityBrain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CYP7B1ID40255ch8q21.html";