LMPD Database

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LMP000594

UniProt Annotations

Entry Information
Gene Namemultiple inositol-polyphosphate phosphatase 1
Protein EntryMINP1_HUMAN
UniProt IDQ9UNW1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q9UNW1-1; Sequence=Displayed; Name=2; IsoId=Q9UNW1-2; Sequence=VSP_014552, VSP_014555; Note=No experimental confirmation available.; Name=3; IsoId=Q9UNW1-3; Sequence=VSP_014553, VSP_014554; Note=No experimental confirmation available.; Name=4; IsoId=Q9UNW1-4; Sequence=VSP_044569; Note=No experimental confirmation available.;
Biophysicochemical PropertiesKinetic parameters: KM=0.61 mM for 2,3-bisphosphoglycerate ; Vmax=15.8 nmol/min/mg enzyme with 2,3-bisphospho-D-glycerate as substrate ;
Catalytic Activity2,3-bisphospho-D-glycerate + H(2)O = 2- phospho-D-glycerate + phosphate.
Catalytic ActivityMyo-inositol hexakisphosphate + H(2)O = myo- inositol pentakisphosphate (mixed isomers) + phosphate.
DiseaseNote=Defects in MINPP1 may be involved in follicular thyroid tumors development.
FunctionActs as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification).
Sequence CautionSequence=BAD93056.1; Type=Erroneous initiation; Evidence= ;
SimilarityBelongs to the histidine acid phosphatase family. MINPP1 subfamily.
Subcellular LocationEndoplasmic reticulum lumen .
Tissue SpecificityWidely expressed with highest levels in kidney, liver and placenta.