LMPD Database

LMP000594

Record overview

LMPD ID	LMP000594
Gene ID	9562
Species	Homo sapiens (Human)
Gene Name	multiple inositol-polyphosphate phosphatase 1
Gene Symbol	MINPP1
Synonyms	HIPER1; MINPP2; MIPP
Alternate names	multiple inositol polyphosphate phosphatase 1; 2,3-BPG phosphatase; ins(1,3,4,5)P(4) 3-phosphatase; 2,3-bisphosphoglycerate 3-phosphatase; multiple inositol polyphosphate phosphatase 2; inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase; multiple inositol polyphosphate histidine phosphatase, 1
Chromosome	10
Map Location	10q23
EC Number	3.1.3.62
Summary	This gene encodes multiple inositol polyphosphate phosphatase; an enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]
Orthologs	View orthologs and multiple alignments for MINPP1

Proteins

multiple inositol polyphosphate phosphatase 1 isoform 1 precursor

Refseq ID:	NP_004888
Protein GI:	19923761
UniProt ID:	Q9UNW1
mRNA ID:	NM_004897
Length:	487
RefSeq Status:	VALIDATED

MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIR
KLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQ
HYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSP
WCDVFDIDDAKVLEYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMH
RKFRSGLIVPYASNLIFVLYHCENAKTPKEQFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARANSTSDEL

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2969
peptide sequence: 
MLRAPGCLLRTSVAPAAALAAALLSSLARC

sig_peptide: 1..30
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2969
peptide sequence: 
MLRAPGCLLRTSVAPAAALAAALLSSLARC

mat_peptide: 31..487
product: Multiple inositol polyphosphate phosphatase 1
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9UNW1.1)
calculated_mol_wt: 52101
peptide sequence: 
SLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGGASSTGSRDLGAA
LADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFD
HCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVLEYLNDLKQYWKRGYGYT
INSRSSCTLFQDIFQHLDKAVEQKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLTAYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKE
QFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSCQTSEECELARANSTSDEL

multiple inositol polyphosphate phosphatase 1 isoform 2 precursor

Refseq ID:	NP_001171588
Protein GI:	296010986
UniProt ID:	Q9UNW1
mRNA ID:	NM_001178117
Length:	312
RefSeq Status:	VALIDATED

multiple inositol polyphosphate phosphatase 1 isoform 3
`MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIR KLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQ HYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNAGLSQFLLQSSSSLVMQRLFFHC FLSWATSKTRNP`

Refseq ID:	NP_001171589
Protein GI:	296010986
UniProt ID:	Q9UNW1
mRNA ID:	NM_001178118
Length:	312
RefSeq Status:	VALIDATED

`MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVASSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCTPVQLVALIRHGTRYPTVKQIR KLRQLHGLLQARGSRDGGASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQLALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQGLWQ HYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKFLTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVNDLNAGLSQFLLQSSSSLVMQRLFFHC FLSWATSKTRNP`