LMPD Database

LMP000542

Gene Information

Entrez Gene ID	6857
Gene Name	synaptotagmin I
Gene Symbol	SYT1
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0030054	IEA:UniProtKB-KW	C	cell junction
GO:0060201	TAS:Reactome	C	clathrin-sculpted acetylcholine transport vesicle membrane
GO:0061202	TAS:Reactome	C	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0060203	TAS:Reactome	C	clathrin-sculpted glutamate transport vesicle membrane
GO:0070083	TAS:Reactome	C	clathrin-sculpted monoamine transport vesicle membrane
GO:0031045	IEA:Ensembl	C	dense core granule
GO:0030666	TAS:Reactome	C	endocytic vesicle membrane
GO:0060076	IEA:Ensembl	C	excitatory synapse
GO:0016021	IEA:UniProtKB-KW	C	integral component of membrane
GO:0043005	ISS:ParkinsonsUK-UCL	C	neuron projection
GO:0005886	TAS:Reactome	C	plasma membrane
GO:0042734	IEA:Ensembl	C	presynaptic membrane
GO:0008021	TAS:UniProtKB	C	synaptic vesicle
GO:0030672	IEA:Ensembl	C	synaptic vesicle membrane
GO:0005545	TAS:UniProtKB	F	1-phosphatidylinositol binding
GO:0005544	ISS:ParkinsonsUK-UCL	F	calcium-dependent phospholipid binding
GO:0005509	IEA:Ensembl	F	calcium ion binding
GO:0050750	IDA:MGI	F	low-density lipoprotein particle receptor binding
GO:0005546	IEA:Ensembl	F	phosphatidylinositol-4,5-bisphosphate binding
GO:0001786	IEA:Ensembl	F	phosphatidylserine binding
GO:0000149	ISS:ParkinsonsUK-UCL	F	SNARE binding
GO:0017075	TAS:UniProtKB	F	syntaxin-1 binding
GO:0005215	IEA:InterPro	F	transporter activity
GO:0048791	ISS:ParkinsonsUK-UCL	P	calcium ion-dependent exocytosis of neurotransmitter
GO:0005513	TAS:UniProtKB	P	detection of calcium ion
GO:0014047	TAS:Reactome	P	glutamate secretion
GO:0007269	TAS:UniProtKB	P	neurotransmitter secretion
GO:0045956	IEA:Ensembl	P	positive regulation of calcium ion-dependent exocytosis
GO:0050806	ISS:ParkinsonsUK-UCL	P	positive regulation of synaptic transmission
GO:0031340	IEA:Ensembl	P	positive regulation of vesicle fusion
GO:0051260	TAS:UniProtKB	P	protein homooligomerization
GO:0017157	TAS:UniProtKB	P	regulation of exocytosis
GO:1903305	ISS:ParkinsonsUK-UCL	P	regulation of regulated secretory pathway
GO:0051966	ISS:ParkinsonsUK-UCL	P	regulation of synaptic transmission, glutamatergic
GO:0007268	TAS:Reactome	P	synaptic transmission
GO:0016079	IEA:Ensembl	P	synaptic vesicle exocytosis
GO:0048278	IEA:Ensembl	P	vesicle docking

KEGG Pathway Links

KEGG Pathway ID	Description
hsa04721	Synaptic vesicle cycle

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_200782	Toxicity of botulinum toxin type B (BoNT/B)
REACT_200743	Toxicity of botulinum toxin type G (BoNT/G)