LMPD Database

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LMP000542

Record overview

LMPD IDLMP000542
Gene ID6857
SpeciesHomo sapiens (Human)
Gene Namesynaptotagmin I
Gene SymbolSYT1
SynonymsP65; SVP65; SYT
Chromosome12
Map Location12cen-q21
SummaryThe synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
OrthologsView orthologs and multiple alignments for SYT1

Proteins

synaptotagmin-1 isoform 1
Refseq ID:NP_001129277
Protein GI:209447070
UniProt ID:P21579
mRNA ID:NM_001135805
Length:422
RefSeq Status:VALIDATED
MVSESHHEALAAPPVTTVATVLPSNATEPASPGEGKEDAFSKLKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKN
AINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHR
KTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNL
KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRR
PIAQWHTLQVEEEVDAMLAVKK
 
synaptotagmin-1 isoform 1
Refseq ID:NP_001129278
Protein GI:209447073
UniProt ID:P21579
mRNA ID:NM_001135806
Length:422
RefSeq Status:VALIDATED
Protein sequence is identical to GI:209447070 (mRNA isoform)
 
synaptotagmin-1 isoform 1
Refseq ID:NP_005630
Protein GI:5032139
UniProt ID:P21579
mRNA ID:NM_005639
Length:422
RefSeq Status:VALIDATED
Protein sequence is identical to GI:209447070 (mRNA isoform)
 
synaptotagmin-1 isoform 2
Refseq ID:NP_001278830
Protein GI:631790805
UniProt ID:J3KQA0
mRNA ID:NM_001291901
Length:419
RefSeq Status:VALIDATED
MVSESHHEALAAPPVTTVATVLPSNATEPASPGEGKEDAFSKLKEKFMNELHKIPLPPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKN
AINMKDVKDLGKTMKDQDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTL
NPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKM
DVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIA
QWHTLQVEEEVDAMLAVKK