LMPD Database

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LMP000534

UniProt Annotations

Entry Information
Gene Namephosphomevalonate kinase
Protein EntryPMVK_HUMAN
UniProt IDQ15126
SpeciesHuman
Comments
Comment typeDescription
Biophysicochemical PropertiesKinetic parameters: KM=25 uM for (R)-5-phosphomevalonate ; KM=0.26 mM for ATP {ECO
Catalytic ActivityATP + (R)-5-phosphomevalonate = ADP + (R)-5- diphosphomevalonate.
InductionBy sterol.
PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.
Subcellular LocationPeroxisome .
SubunitMonomer.
Tissue SpecificityHeart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung.