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LMP000534

Record overview

LMPD IDLMP000534
Gene ID10654
SpeciesHomo sapiens (Human)
Gene Namephosphomevalonate kinase
Gene SymbolPMVK
SynonymsHUMPMKI; PMK; PMKA; PMKASE
Alternate namesphosphomevalonate kinase; hPMK
Chromosome1
Map Location1q22
EC Number2.7.4.2
SummaryThis gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]
OrthologsView orthologs and multiple alignments for PMVK

Proteins

phosphomevalonate kinase
Refseq ID:NP_006547
Protein GI:5729980
UniProt ID:Q15126
mRNA ID:NM_006556
Length:192
RefSeq Status:VALIDATED
MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGIS
QPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL