LMPD Database

LMP000514

Gene Information

Entrez Gene ID	5164
Gene Name	pyruvate dehydrogenase kinase, isozyme 2
Gene Symbol	PDK2
Species	Homo sapiens

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005759	TAS:Reactome	C	mitochondrial matrix
GO:0005967	ISS:UniProtKB	C	mitochondrial pyruvate dehydrogenase complex
GO:0005524	IDA:UniProtKB	F	ATP binding
GO:0042803	IPI:UniProtKB	F	protein homodimerization activity
GO:0004672	TAS:ProtInc	F	protein kinase activity
GO:0004674	IEA:UniProtKB-KW	F	protein serine/threonine kinase activity
GO:0004740	IDA:UniProtKB	F	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0044237	TAS:Reactome	P	cellular metabolic process
GO:0031670	ISS:UniProtKB	P	cellular response to nutrient
GO:0034614	IMP:UniProtKB	P	cellular response to reactive oxygen species
GO:0042593	ISS:UniProtKB	P	glucose homeostasis
GO:0006006	TAS:ProtInc	P	glucose metabolic process
GO:0008286	ISS:UniProtKB	P	insulin receptor signaling pathway
GO:0072332	IMP:UniProtKB	P	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0006468	IDA:GOC	P	protein phosphorylation
GO:0006090	TAS:Reactome	P	pyruvate metabolic process
GO:0010510	ISS:UniProtKB	P	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0010565	ISS:UniProtKB	P	regulation of cellular ketone metabolic process
GO:0006111	ISS:UniProtKB	P	regulation of gluconeogenesis
GO:0010906	ISS:UniProtKB	P	regulation of glucose metabolic process
GO:0006885	ISS:UniProtKB	P	regulation of pH
GO:0044281	TAS:Reactome	P	small molecule metabolic process

REACTOME Pathway Links

REACTOME Pathway ID	Description
REACT_2071	Pyruvate metabolism
REACT_1046	Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_12528	Regulation of pyruvate dehydrogenase (PDH) complex