LMPD Database

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LMP000514

Record overview

LMPD IDLMP000514
Gene ID5164
SpeciesHomo sapiens (Human)
Gene Namepyruvate dehydrogenase kinase, isozyme 2
Gene SymbolPDK2
SynonymsPDHK2; PDKII
Alternate namespyruvate dehydrogenase kinase, isozyme 2; PDH kinase 2; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
Chromosome17
Map Location17q21.33
EC Number2.7.11.2
SummaryThis gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
OrthologsView orthologs and multiple alignments for PDK2

Proteins

pyruvate dehydrogenase kinase, isozyme 2 isoform 1 precursor
Refseq ID:NP_002602
Protein GI:19923736
UniProt ID:Q15119
mRNA ID:NM_002611
Length:407
RefSeq Status:REVIEWED
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLD
KDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEV
VKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKI
ERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKN
TSTYRVS
 
pyruvate dehydrogenase kinase, isozyme 2 isoform 2
Refseq ID:NP_001186827
Protein GI:315630349
UniProt ID:Q15119
mRNA ID:NM_001199898
Length:343
RefSeq Status:REVIEWED
MKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRIS
IRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESH
ESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALS
TDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
 
pyruvate dehydrogenase kinase, isozyme 2 isoform 2
Refseq ID:NP_001186828
Protein GI:315630351
UniProt ID:Q15119
mRNA ID:NM_001199899
Length:343
RefSeq Status:REVIEWED
Protein sequence is identical to GI:315630349 (mRNA isoform)