LMPD Database

LMP000503

Gene Information

Entrez Gene ID	16846
Gene Name	leptin
Gene Symbol	Lep
Species	Mus musculus

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	IDA:BHF-UCL	C	cytoplasm
GO:0005576	TAS:Reactome	C	extracellular region
GO:0005615	IDA:BHF-UCL	C	extracellular space
GO:0008083	IDA:MGI	F	growth factor activity
GO:0060612	IGI:MGI	P	adipose tissue development
GO:0008343	IDA:HGNC	P	adult feeding behavior
GO:0008206	IDA:MGI	P	bile acid metabolic process
GO:0035630	IEA:Ensembl	P	bone mineralization involved in bone maturation
GO:0071298	IEA:Ensembl	P	cellular response to L-ascorbic acid
GO:0071300	IEA:Ensembl	P	cellular response to retinoic acid
GO:0021954	IMP:MGI	P	central nervous system neuron development
GO:0008203	IGI:MGI	P	cholesterol metabolic process
GO:0007623	IEA:Ensembl	P	circadian rhythm
GO:0042755	IGI:MGI	P	eating behavior
GO:0006112	IEA:Ensembl	P	energy reserve metabolic process
GO:0006635	IGI:MGI	P	fatty acid beta-oxidation
GO:0007565	IEA:Ensembl	P	female pregnancy
GO:0042593	IGI:MGI	P	glucose homeostasis
GO:0006006	IMP:MGI	P	glucose metabolic process
GO:0006114	IEA:Ensembl	P	glycerol biosynthetic process
GO:0042445	IMP:MGI	P	hormone metabolic process
GO:0030073	IGI:MGI	P	insulin secretion
GO:0033210	IEA:Ensembl	P	leptin-mediated signaling pathway
GO:0050901	IEA:Ensembl	P	leukocyte tethering or rolling
GO:0006629	IMP:MGI	P	lipid metabolic process
GO:0043066	IEA:Ensembl	P	negative regulation of apoptotic process
GO:0032099	IDA:HGNC	P	negative regulation of appetite
GO:0061037	IEA:Ensembl	P	negative regulation of cartilage development
GO:0070093	IDA:BHF-UCL	P	negative regulation of glucagon secretion
GO:2000486	IEA:Ensembl	P	negative regulation of glutamine transport
GO:0000122	IDA:BHF-UCL	P	negative regulation of transcription from RNA polymerase II promoter
GO:0045906	IEA:Ensembl	P	negative regulation of vasoconstriction
GO:0001542	IEA:Ensembl	P	ovulation from ovarian follicle
GO:0001890	IEA:Ensembl	P	placenta development
GO:0008284	IEA:Ensembl	P	positive regulation of cell proliferation
GO:0001819	IEA:Ensembl	P	positive regulation of cytokine production
GO:0048639	IEA:Ensembl	P	positive regulation of developmental growth
GO:0046881	IEA:Ensembl	P	positive regulation of follicle-stimulating hormone secretion
GO:2000491	IEA:Ensembl	P	positive regulation of hepatic stellate cell activation
GO:0046628	IEA:Ensembl	P	positive regulation of insulin receptor signaling pathway
GO:0043270	IEA:Ensembl	P	positive regulation of ion transport
GO:0046427	IDA:BHF-UCL	P	positive regulation of JAK-STAT cascade
GO:0033686	IEA:Ensembl	P	positive regulation of luteinizing hormone secretion
GO:0043410	IEA:Ensembl	P	positive regulation of MAPK cascade
GO:0045639	IDA:MGI	P	positive regulation of myeloid cell differentiation
GO:0042307	IDA:BHF-UCL	P	positive regulation of protein import into nucleus
GO:2000366	IDA:BHF-UCL	P	positive regulation of STAT protein import into nucleus
GO:0042517	IEA:Ensembl	P	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0008217	IEA:Ensembl	P	regulation of blood pressure
GO:0045598	IGI:MGI	P	regulation of fat cell differentiation
GO:0006111	IMP:MGI	P	regulation of gluconeogenesis
GO:0050796	IMP:MGI	P	regulation of insulin secretion
GO:0030300	IDA:MGI	P	regulation of intestinal cholesterol absorption
GO:0060587	IEA:Ensembl	P	regulation of lipoprotein lipid oxidation
GO:0019222	IMP:MGI	P	regulation of metabolic process
GO:1900180	IMP:MGI	P	regulation of protein localization to nucleus
GO:0001932	IDA:BHF-UCL	P	regulation of protein phosphorylation
GO:0050810	IMP:MGI	P	regulation of steroid biosynthetic process
GO:0002021	IMP:MGI	P	response to dietary excess
GO:0001666	IEA:Ensembl	P	response to hypoxia
GO:0032868	IMP:MGI	P	response to insulin
GO:0033197	IEA:Ensembl	P	response to vitamin E
GO:0007260	IDA:BHF-UCL	P	tyrosine phosphorylation of STAT protein

KEGG Pathway Links

KEGG Pathway ID	Description
mmu04152	AMPK signaling pathway
mmu04932	Non-alcoholic fatty liver disease (NAFLD)