LMPD Database

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LMP000478

UniProt Annotations

Entry Information
Gene Namenuclear receptor subfamily 1, group H, member 4
Protein EntryNR1H4_HUMAN
UniProt IDQ96RI1
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q96RI1-3; Sequence=Displayed; Name=2; IsoId=Q96RI1-4; Sequence=VSP_003665; Name=3; IsoId=Q96RI1-1; Sequence=VSP_010135; Name=4; IsoId=Q96RI1-2; Sequence=VSP_010135, VSP_003665; Name=5; IsoId=Q96RI1-5; Sequence=VSP_010135, VSP_044547; Note=No experimental confirmation available.;
FunctionLigand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. {ECO
PtmMethylation may increase transactivation of target genes.
Sequence CautionSequence=BC144183; Type=Frameshift; Positions=156; Evidence= ;
SimilarityBelongs to the nuclear hormone receptor family. NR1 subfamily.
SimilarityContains 1 nuclear receptor DNA-binding domain.
Subcellular LocationNucleus .
SubunitHeterodimer of NR1H4 and RXR. After activation by agonist binding, interacts with a coactivator, NCOA1 or NCOA2 (By similarity). Interacts with CARM1 and SMARD1. {ECO
Web ResourceName=Wikipedia; Note=Farnesoid X receptor entry; URL="http://en.wikipedia.org/wiki/Farnesoid_X_receptor";