LMPD Database

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LMP000442

UniProt Annotations

Entry Information
Gene Namealpha 1,4-galactosyltransferase
Protein EntryA4GAT_HUMAN
UniProt IDQ9NPC4
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + beta-D-galactosyl- (1->4)-D-glucosyl-(1<->1)-ceramide = UDP + alpha-D-galactosyl- (1->4)-beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide.
DomainThe conserved DXD motif is involved in enzyme activity.
FunctionNecessary for the biosynthesis of the Pk antigen of blood histogroup P. Catalyzes the transfer of galactose to lactosylceramide and galactosylceramide. Necessary for the synthesis of the receptor for bacterial verotoxins.
PathwayProtein modification; protein glycosylation.
PolymorphismGenetic variation in A4GALT is responsible for the P system blood group phenotypes [MIM
SimilarityBelongs to the glycosyltransferase 32 family.
Subcellular LocationGolgi apparatus membrane ; Single-pass type II membrane protein .
Tissue SpecificityUbiquitous. Highly expressed in kidney, heart, spleen, liver, testis and placenta.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=Lactosylceramide 4-alpha-galactosyltransferase; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_428";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=A4GALT";
Web ResourceName=SeattleSNPs; URL="http://pga.gs.washington.edu/data/a4galt/";