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LMP000442

Record overview

LMPD IDLMP000442
Gene ID53947
SpeciesHomo sapiens (Human)
Gene Namealpha 1,4-galactosyltransferase
Gene SymbolA4GALT
SynonymsA14GALT; A4GALT1; Gb3S; P(k); P1; P1PK; PK
Alternate nameslactosylceramide 4-alpha-galactosyltransferase; GB3 synthase; alpha4Gal-T1; CD77 synthase; P1/Pk synthase; P(k) antigen synthase; P blood group (P one antigen); globotriaosylceramide synthase; alpha-1,4-N-acetylglucosaminyltransferase; UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
Chromosome22
Map Location22q13.2
EC Number2.4.1.228
SummaryThe protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for A4GALT

Proteins

lactosylceramide 4-alpha-galactosyltransferase
Refseq ID:NP_059132
Protein GI:8392830
UniProt ID:Q9NPC4
mRNA ID:NM_017436
Length:353
RefSeq Status:REVIEWED
MSKPPDLLLRLLRGAPRQRVCTLFIIGFKFTFFVSIMIYWHVVGEPKEKGQLYNLPAEIPCPTLTPPTPPSHGPTPGNIFFLETSDRTNPNFLFMCSVES
AARTHPESHVLVLMKGLPGGNASLPRHLGISLLSCFPNVQMLPLDLRELFRDTPLADWYAAVQGRWEPYLLPVLSDASRIALMWKFGGIYLDTDFIVLKN
LRNLTNVLGTQSRYVLNGAFLAFERRHEFMALCMRDFVDHYNGWIWGHQGPQLLTRVFKKWCSIRSLAESRACRGVTTLPPEAFYPIPWQDWKKYFEDIN
PEELPRLLSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEAMKMYL