LMPD Database

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LMP000352

UniProt Annotations

Entry Information
Gene Nameprotein kinase, AMP-activated, beta 1 non-catalytic subunit
Protein EntryAAKB1_HUMAN
UniProt IDQ9Y478
SpeciesHuman
Comments
Comment typeDescription
DomainThe glycogen-binding domain may target AMPK to glycogen so that other factors like glycogen-bound debranching enzyme or protein phosphatases can directly affect AMPK activity.
FunctionNon-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
InteractionO70302:Cidea (xeno); NbExp=4; IntAct=EBI-719769, EBI-7927848; P62993:GRB2; NbExp=2; IntAct=EBI-719769, EBI-401755; Q13131:PRKAA1; NbExp=5; IntAct=EBI-719769, EBI-1181405; P54619:PRKAG1; NbExp=4; IntAct=EBI-719769, EBI-1181439;
PtmPhosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. {ECO
Sequence CautionSequence=AAB71326.1; Type=Erroneous gene model prediction; Evidence= ; Sequence=AAC98897.1; Type=Frameshift; Positions=245; Evidence= ;
SimilarityBelongs to the 5'-AMP-activated protein kinase beta subunit family.
SubunitAMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. {ECO
Web ResourceName=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PRKAB1ID44100ch12q24.html";