LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP000323

UniProt Annotations

Entry Information
Gene Nameprostaglandin E receptor 1 (subtype EP1), 42kDa
Protein EntryPE2R1_HUMAN
UniProt IDP34995
SpeciesHuman
Comments
Comment typeDescription
FunctionReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.
PtmPhosphorylated.
Sequence CautionSequence=BAC05723.1; Type=Erroneous gene model prediction; Evidence= ;
SimilarityBelongs to the G-protein coupled receptor 1 family.
Subcellular LocationCell membrane; Multi-pass membrane protein.
Tissue SpecificityAbundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.