LMPD Database

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LMP000323

Record overview

LMPD IDLMP000323
Gene ID5731
SpeciesHomo sapiens (Human)
Gene Nameprostaglandin E receptor 1 (subtype EP1), 42kDa
Gene SymbolPTGER1
SynonymsEP1
Alternate namesprostaglandin E2 receptor EP1 subtype; prostanoid EP1 receptor; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1, subtype EP1; prostaglandin E receptor 1 (subtype EP1), 42kD
Chromosome19
Map Location19p13.1
SummaryThe protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PTGER1

Proteins

prostaglandin E2 receptor EP1 subtype
Refseq ID:NP_000946
Protein GI:38505194
UniProt ID:P34995
mRNA ID:NM_000955
Length:402
RefSeq Status:REVIEWED
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYT
AGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQ
ALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLV
GIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLS
HF