LMPD Database

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LMP000085

UniProt Annotations

Entry Information
Gene NameABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase, transferase B, alpha 1-3-galactosyltransferase)
Protein EntryBGAT_MOUSE
UniProt IDP38649
SpeciesMouse
Comments
Comment typeDescription
Catalytic ActivityUDP-alpha-D-galactose + alpha-L-fucosyl- (1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L- fucosyl-(1->2))-D-galactosyl-R.
Catalytic ActivityUDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1->3)-(alpha-L- fucosyl-(1->2))-beta-D-galactose.
CofactorName=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250}; Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250};
DomainThe conserved DXD motif is involved in cofactor binding. The manganese ion interacts with the beta-phosphate group of UDP and may also have a role in catalysis.
PathwayProtein modification; protein glycosylation.
Sequence CautionSequence=CAM23695.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
SimilarityBelongs to the glycosyltransferase 6 family. {ECO:0000305}.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid (By similarity). {ECO:0000250}.
Tissue SpecificitySubmaxillary glands (at protein level). {ECO:0000269|PubMed:11278752}.