LMPD Database

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LMP013603

UniProt Annotations

Entry Information
Gene Nameperilipin 5
Protein EntryPLIN5_RAT
UniProt IDM0R7Z9
SpeciesRat
Comments
Comment typeDescription
FunctionLipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. {ECO:0000269|PubMed:21885430, ECO:0000269|PubMed:22127648, ECO:0000269|PubMed:23353597}.
PtmPhosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation
SimilarityBelongs to the perilipin family
Subcellular LocationLipid droplet. Cytoplasm. Mitochondrion. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm (By similarity)
SubunitHomooligomer. Interacts with PNPLA2; prevents interaction of PNPLA2 with ABHD5. Interacts with ABHD5; targets ABHD5 to lipid droplets and promotes interaction of ABHD5 with PNPLA2. Interacts with LIPE. {ECO:0000269|PubMed:23408028, ECO:0000269|PubMed:24303154}.